Response to Pearl's comments on principal stratification.
نویسنده
چکیده
Dr. Pearl invites researchers to justify their use of principal stratification. This comment explains how the use of principal stratification simplified a complex mediational problem encountered when evaluating a smoking cessation intervention's effect on reducing smoking withdrawal symptoms.
منابع مشابه
Clarifying the role of principal stratification in the paired availability design.
The paired availability design for historical controls postulated four classes corresponding to the treatment (old or new) a participant would receive if arrival occurred during either of two time periods associated with different availabilities of treatment. These classes were later extended to other settings and called principal strata. Judea Pearl asks if principal stratification is a goal o...
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Abstract We extend Pearl's criticisms of principal stratification analysis as a method for interpreting and adjusting for intermediate variables in a causal analysis. We argue that this can be meaningful only in those rare cases that involve strong functional dependence, and even then may not be appropriate.
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Pearl's article provides a useful springboard for discussing further the benefits and drawbacks of principal stratification and the associated discomfort with attributing effects to post-treatment variables. The basic insights of the approach are important: pay close attention to modification of treatment effects by variables not observable before treatment decisions are made, and be careful in...
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This commentary takes up Pearl's welcome challenge to clearly articulate the scientific value of principal stratification estimands that we and colleagues have investigated, in the area of randomized placebo-controlled preventive vaccine efficacy trials, especially trials of HIV vaccines. After briefly arguing that certain principal stratification estimands for studying vaccine effects on post-...
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ورودعنوان ژورنال:
- The international journal of biostatistics
دوره 7 1 شماره
صفحات -
تاریخ انتشار 2011